Endometrial Protection in HRT

In April 2024, The British Menopause Society released a new joint guideline which has made suggested changes to the dose of progesterone for women on oestrogen for HRT. 
This comprehensive new Guideline was produced by the British Menopause Society (BMS) in partnership with the British Society of Gynaecological Endoscopy, British Gynaecological Cancer Society, Faculty of Sexual & Reproductive Healthcare, Getting It Right First Time (GIRFT) and the Royal College of Obstetricians & Gynaecologists, in response to the significant increase in women presenting with unscheduled bleeding on HRT.

Management of unscheduled bleeding on hormone replacement therapy (HRT)
The progestogen dose change only applies to women on the high dose oestrogen regimens. 

If you are taking any of the preparations in the table below, at the high dose regimens, the progestogen dose needs to be balanced to reduce the risk of endometrial cancer and unscheduled bleeding. 

We are looking to change women to the higher doses outlined below and so you may see a change in your prescription. If this change has not been made, please contact Henfield Medical Centre via admin Rapid Health link on our website to discuss the change.

Progesterone dose table
Page last reviewed: 05 June 2025
Page created: 05 June 2025